Fluorescence Slide Scanner

Fluorescent markers have become the main means of obtaining clear contrast under light microscopy. They can easily visualize molecules, organelles and cell types, which is of crucial importance for highly accurate localization and transport studies. The fluorescence slide scanner system can be extended to scan fluorescent samples. A slide with complete fluorescence records can be analyzed in detail without the risk of cell fading or damage. Each component within the fluorescence slide scanner system is carefully designed to work in synergy, creating a fully automated, high-speed multi-channel fluorescence scanning system that exhibits remarkable flexibility and convenient operability.

Fluorescence Scanning

Bright-field Scanning

 

The in situ distribution of the HER2 gene on the chromatin within the nuclei of cancer tissue was demonstrated by fluorescence in situ hybridization (FISH). As an important tumor marker, it is widely used in clinical practice for the identification of breast cancer types and the prediction of prognosis.

S-Shaped Scaning

Large target camera make scanning faster

 

S-shaped trajectory scanning method save scanning time and improve scanning accuracy. (fig.A S-shaped scanning, fig.B Others Line scaning,Z-type one-way scanning).CMOS sensor with high resolution and 43 fps acquisition speed.

15s(20X 15×15 Mm)

High speed Scanner (Ultra-high Precision Motion Control)

 

Piezoelectric Ceramic Stacked Nano- s tage(fig.C). The self-developed piezoelectric ceramic stacked nano- stage controls the axis, Total stroke >150μm,small signal (20μm stroke,positioning time 40ms)resolution 10nm, fast and precise focus positioning.

Double Objectives(NA. 0.95)

High resolution optical imaging

 

Self-developed high-speed stroboscopic light source, which instantly provides ultra-high-power illumination(150 flashes/s) through stroboscopic mode,ensuringenough luminous flux,uniform illumination,and clearer imagingduring high-speed scanning.Another feature of the stroboscopic light source is the low temperature effect during long-term work,which has a protective effect on the sample.

Auto-Focus

Dynamic pre-focusing on entire specimen

 

The EScan series can select focus according to different tissues. Focus check points within a scanned slide are automatically determined. It analyzes focus status right before capturing an image and adjusts the objective lens to focus the image in real time.

Z- Stack

Z-stack Extended Focus

 

lmproves your image quality when analyzing thick samples. Acquiring the high resolution digitized images of thick samples which have 3D structures such as clumps of cells and thick tissues(Approx. 20μm).

Automatic System Calibration

Automatic system calibration

 

Based on the special database limit compression technology of artificial intelligence algorithm, the storage space and cost are greatly saved without affecting the imaging quality.

 

Automatic recognition of different slide types

H&E,IHC,Special Stains

Apply to histopathology, tissue section, cell pathology,TCT exfoliated cell smear, etc

Easy-to-use

With an intuitive interface and rapid one-click scanning capabilities, the fluorescence slide scanner beautifully combines simplicity of use with sophisticated imaging technologies, ensuring maximal system usage and adoption.

High resolution imaging

Fluorescence slide scanners have extremely high imaging resolution and can capture subtle changes in fluorescence signals, providing scientific researchers with accurate data support.

Efficient and fast

The fluorescence slide scanner uses advanced automation technology to quickly complete the detection of a large number of samples, greatly improving scientific research efficiency.

Diverse fluorescent labeling technologies

The fluorescent slide scanner supports a variety of fluorescent labeling technologies, such as fluorescence in situ hybridization (fish), immunofluorescence, etc., providing scientific researchers with a wealth of experimental methods.

1. Biomedical Research Field

In terms of Cell Biology: It is used to observe the distribution and dynamic changes of various organelles within cells. For example, to study the morphological changes and migration of mitochondria during cell metabolism. By fluorescently labeling mitochondrial-related proteins, the fluorescence slide scanner system can track the behavior of mitochondria under different physiological and pathological conditions with high resolution over a long period of time, thus enabling a deeper understanding of the mechanisms of cell energy metabolism and the pathogenesis of related diseases (such as neurodegenerative diseases).

In terms of Molecular Biology: It is used to localize and quantitatively analyze the expression products (such as proteins, mRNA) of specific genes. For instance, when studying tumor-related genes, fluorescently labeled nucleic acid probes or antibodies can be utilized to detect the expression level and distribution location of specific genes in tumor cells, thereby providing a basis for the early diagnosis of tumors and the discovery of therapeutic targets.

In terms of Developmental Biology: It is used to observe the differentiation of cells and the formation of tissues and organs during embryonic development. In the early stages of embryonic development, different cell types begin to express specific genes. By fluorescently labeling these cell-specific markers, the scanner can record the process of cell differentiation in space and time, helping scientists understand the complex mechanisms of embryonic development and the causes of congenital diseases resulting from developmental abnormalities.

2. Pathology Diagnosis Field

In terms of Tumor Pathology: It assists pathologists in making accurate diagnoses of tumor tissues. It can quickly scan a large number of pathological slices and detect specific markers of tumor cells, such as certain cancer-related proteins (such as HER-2 protein in breast cancer). This not only helps to determine the type and grading of tumors but also provides crucial information for subsequent personalized treatment regimens (such as targeted treatment).

In terms of Infectious Disease Pathology: For some infectious diseases, such as viral infections, by fluorescently labeling viral antigens or markers of the host cell's response to viral infection, it is possible to quickly locate the virus-infected cells in tissue slices and observe the replication and spread of the virus within the cells, which is helpful for timely diagnosis and assessment of the severity of the disease.

3. Drug Research and Development Field

In terms of Drug Target Validation: It is used to validate drug action targets at the cell and tissue levels. For example, when screening anti-tumor drugs, by fluorescently labeling drug target proteins and related signaling pathway molecules, the scanner is used to observe the changes in these targets after drug treatment, including their expression levels, distributions, and activity states, thereby determining whether the drug can effectively act on the expected targets and providing evidence for the further development of the drug.

In terms of Drug Efficacy Evaluation: It is used to evaluate the therapeutic effects of drugs on cells and tissues. The changes in cell morphology, physiological functions, and related markers before and after drug treatment can be compared. For example, to observe the induction of apoptosis in cancer cells by drugs. By detecting the fluorescently labeled apoptosis-related protein (such as Caspase-3), it is determined whether the drug can effectively induce the death of cancer cells, thereby providing an intuitive basis for the evaluation of drug efficacy.

4. Genetics Field

In terms of Gene Location and Chromosome Analysis: In the fluorescence in situ hybridization (FISH) technique, the fluorescence slide scanner is used to observe the changes in the location and copy number of specific genes on chromosomes. For example, when diagnosing genetic diseases related to chromosomal abnormalities (such as Down syndrome), by fluorescently labeling chromosome-specific DNA sequences, the scanner can accurately detect chromosomal number and structural abnormalities, assisting in clinical diagnosis.

In terms of Gene Expression Pattern Research: It is used to study the spatio-temporal expression patterns of different genes in tissues. By constructing transgenic animal models and using fluorescent proteins to label specific genes, the scanner can observe the expression of these genes at different developmental stages and in different tissue locations, helping to understand the functions of genes in the growth, development, and occurrence of diseases in organisms.

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